NSC-12
- Product Name
- NSC-12
- CAS No.
- 102586-30-1
- Chemical Name
- NSC-12
- Synonyms
- CS-2338;CS-2161;NSC172285;NSC12，NSC 172285;NSC-12;NSC 12;NSC12;21-Norchol-5-ene-3,20,23-triol, 24,24,24-trifluoro-23-(trifluoromethyl)-, (3β,20S)-
- CBNumber
- CB23145540
- Molecular Formula
- C24H34F6O3
- Formula Weight
- 484.52
- MOL File
- 102586-30-1.mol
NSC-12 Property
- Boiling point:
- 521.8±45.0 °C(Predicted)
- Density
- 1.31±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 2 mg/ml; DMSO: 0.1 mg/ml; Ethanol: 20 mg/ml; Ethanol:PBS (pH 7.2)(1:2): 0.33 mg/ml
- form
- A crystalline solid
- pka
- 9.50±0.29(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H400Very toxic to aquatic life
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P273Avoid release to the environment.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P391Collect spillage. Hazardous to the aquatic environment
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 20117
- Product name
- NSC 12
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 20117
- Product name
- NSC 12
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $131
- Updated
- 2024/03/01
- Product number
- 20117
- Product name
- NSC 12
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $230
- Updated
- 2024/03/01
- Product number
- 20117
- Product name
- NSC 12
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $494
- Updated
- 2024/03/01
- Product number
- DC9945
- Product name
- NSC-12
- Purity
- >98%
- Packaging
- 250mg
- Price
- $1750
- Updated
- 2021/12/16
NSC-12 Chemical Properties,Usage,Production
Biological Activity
NSC12 (NSC 172285) is an orally available inhibitor of FGF2/FGFR interaction with potential antitumor activity.
in vitro
NSC-12 can inhibit FGF-dependent tumor growth, angiogenesis and metastasis. It did not affect FGF2/heparin interaction, but inhibited FGF2 binding to immobilized receptors (IC50 ~30 μM), it disrupted FGF2 interaction with FGFR1, and had no effect on the interaction activity of growth factors with heparin or HSPGs .
in vivo
Administered by injection and oral route, NSC-12 inhibits FGFR activation, tumor growth, angiogenesis and metastasis in FGF-dependent mouse and human tumor models. In animal models, it significantly reduced tumor weight, tumor cell FGFR1 phosphorylation levels and proliferation, and tumor CD31+ cardiovascular formation.
target
| Target | Value |
| FGF3 (Cell-free assay) | 15.9 μM(Kd) |
| FGF8b (Cell-free assay) | 18.9 μM(Kd) |
| FGF22 (Cell-free assay) | 26.8 μM(Kd) |
| FGF20 (Cell-free assay) | 29.4 μM(Kd) |
| FGF2/FGFR (Cell-free assay) | 30 μM |
NSC-12 Preparation Products And Raw materials
Raw materials
Preparation Products
NSC-12 Suppliers
- Tel
- +1-708-310-1919 +1-13798911105
- Fax
- 708-557-7486
- sales@invivochem.cn
- Country
- United States
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- Advantage
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- Tel
- +1 (732)236-3202
- sales@cckinase.com
- Country
- United States
- ProdList
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- Tel
- +1-833-552-7181
- sales@aladdinsci.com
- Country
- United States
- ProdList
- 57511
- Advantage
- 58
- Tel
- 16314854226
- info@bocsci.com
- Country
- United States
- ProdList
- 9926
- Advantage
- 65